I suspect lockdowns were a factor in increased non-Covid deaths

 Epoch Times:

EXCLUSIVE: Why are Non-COVID Deaths Spiking Among Prime-Age Americans?
...

Drug overdoses skyrocketed in 2020 with more than 20,000 more dying in the 18–64 age group than the year before. The Centers for Disease Control’s (CDC) preliminary data for the first half of 2021 indicates the trend even somewhat intensified.

Deaths involving alcohol—not just alcohol poisoning, but also those due to alcoholic cirrhosis of the liver and other alcohol-induced causes—have been on the rise in recent years, but the 2020 increase was particularly significant. Nearly 8,000 more died in 2020 than the year before in the 18–64 age group. The 2021 data is not yet available.

Homicide deaths increased nearly 30 percent from 2019 to 2020 in the 18–64 age group, accounting for nearly 4,000 excess deaths. Last year is shaping up to be similarly homicidal, based on CDC’s preliminary data for the first half of 2021.

With COVID-19 deaths excluded and assuming drug overdoses, alcohol, and homicide deaths continued in 2021 at a similar intensity as the year before, there was still about 50,000 excess deaths last year in the 18-64 age group.
...

There is much more.

Drug overdoses and alcohol suggest an increase in dealing with depression from being lockdown.  The murders could also be attributed to increased anxiety.

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